反应详情

The 4-nitrobenzenesulfonamide obtained (5.9 g) was dissolved in methanol (100 ml), and after an addition of conc. hydrochloric acid, reduced iron (4.2 g) was added and the mixture stirred at room temperature for 2 hours. After filtration, methanol was evaporated under a reduced pressure, the residue was made basic with an addition of 4N sodium hydroxide, and the mixture of the desired product and iron oxide precipitated was collected by filtration. The mixture was dissolved in acetone (200 ml), filtered to remove iron oxide, and the solvent was evaporated under a reduced pressure to obtain 4-aminobenzenesulfonamide (3.7 g) (m.p. 164° C.-165.5° C.).

1. additionwas added
2. filtrationAfter filtration, methanol
3. customwas evaporated under a reduced pressure
4. additionthe residue was made basic with an addition of 4N sodium hydroxide
5. additionthe mixture of the desired product and iron oxide
6. customprecipitated
7. filtrationwas collected by filtration
8. dissolutionThe mixture was dissolved in acetone (200 ml)
9. filtrationfiltered
10. customto remove iron oxide
11. customthe solvent was evaporated under a reduced pressure