Aluminium lithium hydride → HCID 14330291, compound

HRID 1110796Notes

Reaction equation

HRID 1110796 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[O:10][CH2:9][CH2:8][CH:7]([CH2:11][CH2:12][OH:13])[C:6]=2[CH:14]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].ClC1C=CC2[O:30][CH2:29]CC(CC(OCC)=O)C=2C=1>O1CCCC1>[CH3:29][O:30][C:2]1[CH:3]=[CH:4][C:5]2[O:10][CH2:9][CH2:8][CH:7]([CH2:11][CH2:12][OH:13])[C:6]=2[CH:14]=1

Participants

5

Reactant 3

HCID 21226445Aluminium lithium hydrideHCID 22154276HCID 22154276, compoundHCID 54505136HCID 54505136, compound

Product 1

HCID 14330291HCID 14330291, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-(6-Chloro-3,4-dihydro-1(2H)-benzopyran-4-yl)ethanol may be prepared by proceeding as in Example 1, but starting with lithium aluminium hydride (1.97 g), and ethyl (6-chloro-3,4-dihydro-1(2H)-benzopyran-4-yl)ethanoate (6.6 g) in tetrahydrofuran (120 cc). 2-(6-methoxy-3,4-dihydro-1(2H)-benzopyran-4-yl)ethanol (5.5 g) is thus obtained in the form of a colourless oil.

Sources & evidence

ORD record
ord-1f93185f745446cf95b087505300ef22
Source dataset
uspto-grants-1990_12
Patent number
US04977166

Reaction notes

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