Sodium Hydroxide → HCID 398448, compound

HRID 1110932Notes

Reaction equation

HRID 1110932 reaction equation
[OH-].[Na+].Cl[CH2:4][C:5]([NH:7][C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=[O:11])=[O:6]>O.C(O)(C)C>[NH:7]1[C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10](=[O:12])[O:11][CH2:4][C:5]1=[O:6]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 919916HCID 919916, compound

Product 1

HCID 398448HCID 398448, compoundYield 87%

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 3776IsopropanolSolvent

Conditions

Temperature
80 °C

Procedure

A solution of sodium hydroxide (2 g, 50 mole) in water (12 ml) was added to a stirred slurry of 2-chloroacetamidobenzoic acid (10.3 g, 48 mmole) in isopropanol (22.5 ml) and water (87.5 ml). The mixture was stirred until a solution formed and then heated at 80° C. for 4 hours. The solution was cooled to 0° C. and the crystalline solid collected, washed with water and dried in vacuo at 50° C. to give the product (7.4 g, 87%), m.p. 200°-201° C.

Workup

  1. customformed
  2. temperatureThe solution was cooled to 0° C.
  3. customthe crystalline solid collected
  4. washwashed with water
  5. customdried in vacuo at 50° C.

Sources & evidence

ORD record
ord-2bd37286434e4825823a739ce84aaaae
Source dataset
uspto-grants-1990_12
Patent number
US04977258

Reaction notes

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