7-Chloro-5,6-dihydro-6-oxo-4H-imidazo[1,5-a]-[4,1]benzoxazepine-3-amidoxime → 7-Chloro-3-(5-propyl-1,2,4-oxadiazol-3-yl)-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][4,1]benzoxazepine

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Reaction Steps

7-Chloro-5,6-dihydro-6-oxo-4H-imidazo[1,5-a]-[4,1]benzoxazepine-3-amidoxime (2 g, 7 mmole) in n-butyric anhydride (6 ml) was heated at 150° C. for 1 hour. The crude product was chromatographed on silica, initially with ethyl acetate:hexane (1:1) and then changing to ethyl acetate. The purified product was crystallised from ethyl acetate:cyclohexane (4:1) to give the product (1.2 g, 50%), m.p. 130°-132° C.

Provenance & Evidence