反应详情

7-Chloro-5,6-dihydro-6-oxo-4H-imidazo[1,5-a]-[4,1]benzoxazepine-3-amidoxime (2 g, 7 mmole) in n-butyric anhydride (6 ml) was heated at 150° C. for 1 hour. The crude product was chromatographed on silica, initially with ethyl acetate:hexane (1:1) and then changing to ethyl acetate. The purified product was crystallised from ethyl acetate:cyclohexane (4:1) to give the product (1.2 g, 50%), m.p. 130°-132° C.

1. customThe crude product was chromatographed on silica, initially with ethyl acetate:hexane (1:1)
2. customThe purified product was crystallised from ethyl acetate:cyclohexane (4:1)