HCID 178501025, compound → HCID 178523347, compound

Participants

Reaction Steps

To a solution of methyl 3-(2'-nitroimidazolyl)-2,2-difluoropropionate (1.0 g, 4.2 mmol) in DMF (10 ml), n-butanolamine (500 mg, 5.6 mmol) was added and stirred for 6 hours at a room temperature. Then, the reaction solution was concentrated and purified by silica gel column chromatography to obtain 3-(2'-nitroimidazolyl)-2,2-difluoropropionic acid hydroxybutylamide (450 mg).

Provenance & Evidence