HCID 178501025, compound → HCID 178523347, compound

HRID 1110968Notes

Reaction equation

HRID 1110968 reaction equation
[N+:1]([C:4]1[NH:5][CH:6]=[C:7]([CH2:9][C:10]([F:16])([F:15])[C:11]([O:13]C)=O)[N:8]=1)([O-:3])=[O:2]>CN(C=O)C>[OH:13][CH2:11][CH2:10][CH2:9][CH2:7][NH:8][C:11](=[O:13])[C:10]([F:16])([F:15])[CH2:9][C:7]1[N:8]=[C:4]([N+:1]([O-:3])=[O:2])[NH:5][CH:6]=1

Participants

3

Reactant 1

HCID 178501025HCID 178501025, compound

Product 1

HCID 178523347HCID 178523347, compoundYield 73.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of methyl 3-(2'-nitroimidazolyl)-2,2-difluoropropionate (1.0 g, 4.2 mmol) in DMF (10 ml), n-butanolamine (500 mg, 5.6 mmol) was added and stirred for 6 hours at a room temperature. Then, the reaction solution was concentrated and purified by silica gel column chromatography to obtain 3-(2'-nitroimidazolyl)-2,2-difluoropropionic acid hydroxybutylamide (450 mg).

Workup

  1. concentrationThen, the reaction solution was concentrated
  2. custompurified by silica gel column chromatography

Sources & evidence

ORD record
ord-adaba06181d04d42a2bcc45542294634
Source dataset
uspto-grants-1990_12
Patent number
US04977273

Reaction notes

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