2-Methoxyethylamine → 4-[[2-(2-cyano-4-fluoropyrrolidin-1-yl)-2-oxoethyl]amino]-N-(2-methoxyethyl)bicyclo[2.2.2]octane-1-carboxamide

HRID 111101Notes

Reaction equation

HRID 111101 reaction equation
[C:1](=[O:2])([OH:3])[C:4]12[CH2:5][CH2:6][C:7]([NH:12][CH2:13][C:14](=[O:15])[N:16]3[CH:17]([C:22]#[N:23])[CH2:18][CH:19]([F:21])[CH2:20]3)([CH2:8][CH2:9]1)[CH2:10][CH2:11]2.[CH3:24][O:25][CH2:26][CH2:27][NH2:28]>>[C:1](=[O:3])([C:4]12[CH2:5][CH2:6][C:7]([NH:12][CH2:13][C:14](=[O:15])[N:16]3[CH:17]([C:22]#[N:23])[CH2:18][CH:19]([F:21])[CH2:20]3)([CH2:8][CH2:9]1)[CH2:10][CH2:11]2)[NH:28][CH2:27][CH2:26][O:25][CH3:24]

Participants

3

Reactant 2

HCID 80182-MethoxyethylamineHCID 231496734-[[2-(2-Cyano-4-fluoropyrrolidin-1-yl)-2-oxoethyl]amino]bicyclo[2.2.2]octane-1-carboxylic acid

Product 1

HCID 231506824-[[2-(2-cyano-4-fluoropyrrolidin-1-yl)-2-oxoethyl]amino]-N-(2-methoxyethyl)bicyclo[2.2.2]octane-1-carboxamide

Sources & evidence

ORD record
ord-65e69286657b40c7aae46806fcadb963
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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