Potassium Carbonate → HCID 22153307, compound

Participants

Reaction Steps

1-Trifluoroacetyl-2-(4-bromomethylphenyl)benzimidazole (229.9 g, 0.6 mole) is stirred for 5 hours at room temperature in a 7% solution of potassium carbonate in aqueous methanol The methanolic solution is evaporated to near dryness, and the aqueous residue is extracted with methylene chloride. The combined organics are washed with water, filtered through cotton, and evaporated to yield a solid product which is purified by recrystallization from benzene.

Provenance & Evidence