Potassium Carbonate → HCID 22153307, compound

HRID 1111093Notes

Reaction equation

HRID 1111093 reaction equation
FC(F)(F)C([N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]=[C:6]1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][Br:21])=[CH:16][CH:15]=1)=O.C(=O)([O-])[O-].[K+].[K+]>CO>[Br:21][CH2:20][C:17]1[CH:18]=[CH:19][C:14]([C:6]2[NH:7][C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:5]=2)=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22153312HCID 22153312, compound

Product 1

HCID 22153307HCID 22153307, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-Trifluoroacetyl-2-(4-bromomethylphenyl)benzimidazole (229.9 g, 0.6 mole) is stirred for 5 hours at room temperature in a 7% solution of potassium carbonate in aqueous methanol The methanolic solution is evaporated to near dryness, and the aqueous residue is extracted with methylene chloride. The combined organics are washed with water, filtered through cotton, and evaporated to yield a solid product which is purified by recrystallization from benzene.

Workup

  1. customis evaporated
  2. extractionthe aqueous residue is extracted with methylene chloride
  3. washThe combined organics are washed with water
  4. filtrationfiltered through cotton
  5. customevaporated
  6. customto yield a solid product which
  7. customis purified by recrystallization from benzene

Sources & evidence

ORD record
ord-96caacb9f042421d82d19ba32cd5ca39
Source dataset
uspto-grants-1990_12
Patent number
US04978476

Reaction notes

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