HCID 19768448, compound → HCID 19768452, compound

HRID 1111115Notes

Reaction equation

HRID 1111115 reaction equation
[ClH:1].[O:2]=[C:3]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=[C:6]([C:16]2([NH:22]C=O)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:5]=[CH:4]1>CO>[ClH:1].[NH2:22][C:16]1([C:6]2[CH:5]=[CH:4][C:3](=[O:2])[N:8]([CH2:9][C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:7]=2)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

3

Reactant 1

HCID 19768448HCID 19768448, compound

Product 1

HCID 19768452HCID 19768452, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of N-[1-[1,6-dihydro-6-oxo-1-(phenylmethyl)-3-pyridinyl]-cyclohexyl]formamide hydrochloride (13.4 g) in 200 ml of methanol was heated at reflux for 17 hours. The mixture was cooled, and the resultant crystals were collected, affording 5.6 g of analytically pure 5-(1-aminocyclohexyl)-1-(phenylmethyl)-2(1H)-pyridinone hydrochloride, m.p. 248°-250° C. (dec).

Workup

  1. temperatureat reflux for 17 hours
  2. temperatureThe mixture was cooled
  3. customthe resultant crystals were collected

Sources & evidence

ORD record
ord-baabad889ec74c17985bdd30a8206b44
Source dataset
uspto-grants-1990_12
Patent number
US04978663

Reaction notes

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