Hydrogen Bromide → Dimethyloctylamine hydrobromide

HRID 1111149Notes

Reaction equation

HRID 1111149 reaction equation
[BrH:1].[CH3:2][N:3]([CH3:12])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]>O>[BrH:1].[CH3:2][N:3]([CH3:12])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 16224Dimethyloctylamine

Product 1

HCID 22153594Dimethyloctylamine hydrobromide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Into a 250 ml 3-necked flask equipped with a magnetic stirrer was placed 13.49 g of 48% HBr (0.08 moles) and 60ml of water. The solution was cooled in an ice bath and dimethyloctylamine (12.58 g, 0.08 moles) added dropwise. After the last of the amine had been added (total addition time ca. 30 min) the solution was tested with litmus to assure that it was neutral or acidic, and the water then removed in vacuo. The residue was recrystalized from ethyl acetate and dried under vacuum to give the product, N,N-dimethyl-N-octylamine hydrobromide as a hygroscopic white solid, melting point 156°-158.5° C. (yield 14.01 g, 74%).

Workup

  1. customInto a 250 ml 3-necked flask equipped with a magnetic stirrer
  2. temperatureThe solution was cooled in an ice bath
  3. addition(total addition time ca. 30 min) the solution
  4. customacidic, and the water then removed in vacuo
  5. customThe residue was recrystalized from ethyl acetate
  6. customdried under vacuum

Sources & evidence

ORD record
ord-32ebc3636d9a4b4488b6d18423d681a0
Source dataset
uspto-grants-1990_12
Patent number
US04978685

Reaction notes

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