N-Boc-L-Leucine Hydrate → L-Leucine, N-((1,1-dimethylethoxy)carbonyl)-

HRID 1111181Notes

Reaction equation

HRID 1111181 reaction equation
[NH:1]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].O>C1(C)C=CC=CC=1>[C:10]([NH:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:5])[CH3:6])([O:12][C:13]([CH3:15])([CH3:14])[CH3:16])=[O:11]

Participants

3

Reactant 1

HCID 12373896N-Boc-L-Leucine Hydrate

Product 1

HCID 83170L-Leucine, N-((1,1-dimethylethoxy)carbonyl)-

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

5 g of Boc-Leu-OH.H2O and 100 ml of toluene are mixed in a 500 ml round-bottomed flask with a ground glass neck, and azeotropic evaporation of the water is then carried out twice in succession in a rotary evaporator. The dehydrated product, in the form of an oil, is left overnight in a desiccator over phosphorus pentoxide.

Workup

  1. customazeotropic evaporation of the water
  2. customis then carried out twice in succession in a rotary evaporator

Sources & evidence

ORD record
ord-30e4ced1d5264793a427e82532e4fea0
Source dataset
uspto-grants-1990_12
Patent number
US04978759

Reaction notes

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