N-Boc-L-Leucine Hydrate → L-Leucine, N-((1,1-dimethylethoxy)carbonyl)-

Participants

Reaction Steps

5 g of Boc-Leu-OH.H2O and 100 ml of toluene are mixed in a 500 ml round-bottomed flask with a ground glass neck, and azeotropic evaporation of the water is then carried out twice in succession in a rotary evaporator. The dehydrated product, in the form of an oil, is left overnight in a desiccator over phosphorus pentoxide.

Provenance & Evidence