HCID 15079734, compound → HCID 15079745, compound

HRID 1111199Notes

Reaction equation

HRID 1111199 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]2[CH:15]=[C:16]([C:19]([F:22])([F:21])[F:20])[CH:17]=[CH:18][C:4]=2[N:3]=1.[C:23](OCCC)(=[O:26])[C:24]#[CH:25]>C(O)CC>[F:21][C:19]([F:22])([F:20])[C:16]1[CH:17]=[CH:18][C:4]2[N:3]3[CH:25]=[CH:24][C:23](=[O:26])[N:1]=[C:2]3[CH2:8][N:7]=[C:6]([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:5]=2[CH:15]=1

Participants

4

Reactant 2

HCID 15079734HCID 15079734, compoundHCID 22227298HCID 22227298, compound

Product 1

HCID 15079745HCID 15079745, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

In the manner given in Example 1, 2-amino-7-trifluromethyl-5-phenyl-3H-1,4-benzodiazepine, propyl propiolate and propanol were refluxed. The mixture was chromatographed to give 9-trifluoromethyl-7-phenylpyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Workup

  1. temperaturewere refluxed
  2. customThe mixture was chromatographed

Sources & evidence

ORD record
ord-6882debbdee24638a32297b5eb59fc8b
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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