Methyl propiolate → HCID 15079747, compound

HRID 1111201Notes

Reaction equation

HRID 1111201 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][CH:10]=2)[C:5]2[CH:19]=[C:20]([C:23]#[N:24])[CH:21]=[CH:22][C:4]=2[N:3]=1.[C:25](OC)(=[O:28])[C:26]#[CH:27]>CO>[C:23]([C:20]1[CH:21]=[CH:22][C:4]2[N:3]3[CH:27]=[CH:26][C:25](=[O:28])[N:1]=[C:2]3[CH2:8][N:7]=[C:6]([C:9]3[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][CH:10]=3)[C:5]=2[CH:19]=1)#[N:24]

Participants

4

Reactant 2

HCID 13536Methyl propiolateHCID 15079736HCID 15079736, compound

Product 1

HCID 15079747HCID 15079747, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the manner given in Example 1, 2-amino-7-cyano-5-(p-methylsulfonylphenyl)-3H-1,4-benzodiazepine, methyl propiolate and methanol were refluxed. The mixture was chromatographed to give 9-cyano-7-(p-methylsulfonylphenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Workup

  1. temperaturewere refluxed
  2. customThe mixture was chromatographed

Sources & evidence

ORD record
ord-a05acfd4be6a439ca263726d234a34cb
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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