Methyl propiolate → HCID 15079749, compound

HRID 1111205Notes

Reaction equation

HRID 1111205 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:10]=2[F:16])[C:5]2[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:4]=2[N:3]=1.[C:22](OC)(=[O:25])[C:23]#[CH:24]>CO>[Cl:21][C:18]1[CH:19]=[CH:20][C:4]2[N:3]3[CH:24]=[CH:23][C:22](=[O:25])[N:1]=[C:2]3[CH2:8][N:7]=[C:6]([C:9]3[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:10]=3[F:16])[C:5]=2[CH:17]=1

Participants

4

Reactant 2

HCID 13536Methyl propiolateHCID 15079779HCID 15079779, compound

Product 1

HCID 15079749HCID 15079749, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the manner given in Example 2, 2-amino-7-chloro-5-(2,6-difluorophenyl)-3H-1,4-benzodiazepine, methyl propiolate and methanol were refluxed. The mixture was chromatographed to give 9-chloro-7-(2,6-difluorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Workup

  1. temperaturewere refluxed
  2. customThe mixture was chromatographed

Sources & evidence

ORD record
ord-6765dbc809184e06a43d96ecb1e16cc8
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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