1,1'-Carbonyldiimidazole → HCID 15079770, compound

HRID 1111208Notes

Reaction equation

HRID 1111208 reaction equation
C(N1[CH:12]=[CH:11]N=C1)(N1C=CN=C1)=O.[NH2:13][C:14]1[CH2:20][N:19]=[C:18]([C:21]2[C:26]([F:27])=[CH:25][CH:24]=[CH:23][C:22]=2[F:28])[C:17]2[CH:29]=[C:30]([N+:33]([O-:35])=[O:34])[CH:31]=[CH:32][C:16]=2[N:15]=1.[O:36]1[CH2:40][CH2:39][CH2:38][CH2:37]1.CN(C)C=O>>[N+:33]([C:30]1[CH:31]=[CH:32][C:16]2[N:15]3[C:39]([CH2:40][CH2:11][CH3:12])=[CH:38][C:37](=[O:36])[N:13]=[C:14]3[CH2:20][N:19]=[C:18]([C:21]3[C:26]([F:27])=[CH:25][CH:24]=[CH:23][C:22]=3[F:28])[C:17]=2[CH:29]=1)([O-:35])=[O:34]

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 15079765HCID 15079765, compoundHCID 21974620tetrahydrofuran N,N-dimethylformamide

Product 1

HCID 15079770HCID 15079770, compound

Procedure

In the manner given in Example 16, carbonyldiimidazole, p-hexynoic acid and 2-amino-7-nitro-5-(2,6-difluorophenyl)-3H-1,4-benzodiazepine were stirred in tetrahydrofuran-dimethylformamide to give 9-nitro-1-propyl-7-(2,6-difluorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Sources & evidence

ORD record
ord-572d4f2623b341d09b2a8c0e4116a170
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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