1,1'-Carbonyldiimidazole → HCID 15079772, compound

HRID 1111209Notes

Reaction equation

HRID 1111209 reaction equation
C(N1C=CN=C1)(N1C=CN=C1)=O.[C:13]([OH:19])(=O)[CH2:14][C:15]#[C:16][CH3:17].[NH2:20][C:21]1[CH2:27][N:26]=[C:25]([C:28]2[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=2)[C:24]2[CH:35]=[C:36]([CH2:42][CH3:43])[C:37]([S:39][CH2:40][CH3:41])=[CH:38][C:23]=2[N:22]=1>O1CCCC1.CN(C)C=O>[CH2:40]([S:39][C:37]1[C:36]([CH2:42][CH3:43])=[CH:35][C:24]2[C:25]([C:28]3[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=3)=[N:26][CH2:27][C:21]3[N:22]([C:15]([CH2:16][CH3:17])=[CH:14][C:13](=[O:19])[N:20]=3)[C:23]=2[CH:38]=1)[CH3:41]

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 1421063-Pentynoic acidHCID 15079766HCID 15079766, compound

Product 1

HCID 15079772HCID 15079772, compound

Reagents, catalysts & solvents 1

HCID 21974620tetrahydrofuran N,N-dimethylformamideSolvent

Procedure

In the manner given in Example 16, carbonyldiimidazole, 3-pentynoic acid and 2-amino-8-ethylthio-7-ethyl-5-(p-methylphenyl)-3H-1,4-benzodiazepine were stirred in tetrahydrofuran-dimethylformamide to give 10-ethylthio 1,9-diethyl-7-(p-methylphenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Sources & evidence

ORD record
ord-6735d300c7bb4b8ea93033ca534bc750
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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