1,1'-Carbonyldiimidazole → HCID 22153707, compound

HRID 1111211Notes

Reaction equation

HRID 1111211 reaction equation
C(N1C=CN=C1)(N1C=CN=C1)=O.[CH2:13]([N:15]([CH2:24][CH3:25])[CH2:16][CH2:17][CH2:18][C:19]#[C:20][C:21]([OH:23])=O)[CH3:14].[NH2:26][C:27]1[CH2:33][N:32]=[C:31]([C:34]2[C:39]([F:40])=[CH:38][CH:37]=[CH:36][C:35]=2[F:41])[C:30]2[CH:42]=[C:43]([N+:46]([O-:48])=[O:47])[CH:44]=[CH:45][C:29]=2[N:28]=1>O1CCCC1.CN(C)C=O>[N+:46]([C:43]1[CH:44]=[CH:45][C:29]2[N:28]3[C:19]([CH2:18][CH2:17][CH2:16][N:15]([CH2:13][CH3:14])[CH2:24][CH3:25])=[CH:20][C:21](=[O:23])[N:26]=[C:27]3[CH2:33][N:32]=[C:31]([C:34]3[C:35]([F:41])=[CH:36][CH:37]=[CH:38][C:39]=3[F:40])[C:30]=2[CH:42]=1)([O-:48])=[O:47]

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 15079765HCID 15079765, compoundHCID 22153736HCID 22153736, compound

Product 1

HCID 22153707HCID 22153707, compound

Reagents, catalysts & solvents 1

HCID 21974620tetrahydrofuran N,N-dimethylformamideSolvent

Procedure

In the manner given in Example 21, carbonyldiimidazole, 6-diethylamino-2-hexynoic acid and 2-amino-7-nitro5-(2,6-difluorophenyl)-3H-1,4-benzodiazepine was stirred in tetrahydrofuran-dimethylformamide to give 9-nitro-1-(3-diethylaminopropyl)-7-(2,6-difluorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Sources & evidence

ORD record
ord-45bbab8da65448d7be87bd22ea71504f
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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