1,1'-Carbonyldiimidazole → HCID 22153691, compound

HRID 1111212Notes

Reaction equation

HRID 1111212 reaction equation
C(N1C=CN=C1)(N1C=CN=C1)=O.[N:13]1([CH2:18][C:19]#[C:20][C:21]([OH:23])=O)[CH2:17][CH2:16][CH2:15][CH2:14]1.[NH2:24][C:25]1[CH2:31][N:30]=[C:29]([C:32]2[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][CH:33]=2)[C:28]2[CH:39]=[C:40]([CH2:46][CH3:47])[C:41]([S:43][CH2:44][CH3:45])=[CH:42][C:27]=2[N:26]=1>O1CCCC1.CN(C)C=O>[CH2:44]([S:43][C:41]1[C:40]([CH2:46][CH3:47])=[CH:39][C:28]2[C:29]([C:32]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][CH:33]=3)=[N:30][CH2:31][C:25]3[N:26]([C:19]([CH2:18][N:13]4[CH2:14][CH2:15][CH2:16][CH2:17]4)=[CH:20][C:21](=[O:23])[N:24]=3)[C:27]=2[CH:42]=1)[CH3:45]

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 5725584-pyrrolidin-1-ylbut-2-ynoic acidHCID 15079766HCID 15079766, compound

Product 1

HCID 22153691HCID 22153691, compound

Reagents, catalysts & solvents 1

HCID 21974620tetrahydrofuran N,N-dimethylformamideSolvent

Procedure

In the manner given in Example 21, carbonyldiimidazole, 4-(1-pyrrolidinyl)tetrolic acid, and 2-amino-8-ethylthio-7-ethyl-5-(p-methylphenyl)-3H-1,4-benzodiazepine was stirred in tetrahydrofuran-dimethylformamide to give 10-ethylthio-9-ethyl-1-(1-pyrrolidinylmethyl)-7-(p-methylphenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Sources & evidence

ORD record
ord-ba0c497fb82f4914a42cf60eccb8f0ce
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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