dipropyl but-2-ynedioate → HCID 15079784, compound

HRID 1111217Notes

Reaction equation

HRID 1111217 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:10]=2[F:16])[C:5]2[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:4]=2[N:3]=1.[C:22]([C:30](OCCC)=[O:31])#[C:23][C:24]([O:26][CH2:27][CH2:28][CH3:29])=[O:25]>C(O)CC>[C:24]([C:23]1[N:3]2[C:4]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:5]=3[C:6]([C:9]3[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:10]=3[F:16])=[N:7][CH2:8][C:2]2=[N:1][C:30](=[O:31])[CH:22]=1)([O:26][CH2:27][CH2:28][CH3:29])=[O:25]

Participants

4

Reactant 2

HCID 305766dipropyl but-2-ynedioateHCID 15079779HCID 15079779, compound

Product 1

HCID 15079784HCID 15079784, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

In the manner given in Example 27, 2-amino-7-chloro-5-(2,6-difluorophenyl)-3H-1,4-benzodiazepine was heated in propanol with dipropyl acetylenedicarboxylate to give 1-carbopropoxy-9-chloro-7-(2,6-difluorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Sources & evidence

ORD record
ord-fcd21ca464264e4ba2187c416c4be4ef
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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