Lithium iodide → HCID 15079749, compound

HRID 1111221Notes

Reaction equation

HRID 1111221 reaction equation
C([C:7]1[N:12]2[C:13]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:14]=3[C:15]([C:18]3[C:23]([F:24])=[CH:22][CH:21]=[CH:20][C:19]=3[F:25])=[N:16][CH2:17][C:11]2=[N:10][C:9](=[O:31])[CH:8]=1)(OCCC)=O.[I-].[Li+]>N1C=CC=CC=1>[Cl:30][C:27]1[CH:28]=[CH:29][C:13]2[N:12]3[CH:7]=[CH:8][C:9](=[O:31])[N:10]=[C:11]3[CH2:17][N:16]=[C:15]([C:18]3[C:23]([F:24])=[CH:22][CH:21]=[CH:20][C:19]=3[F:25])[C:14]=2[CH:26]=1

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 15079784HCID 15079784, compound

Product 1

HCID 15079749HCID 15079749, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In the manner given in Example 32, 1-carbopropoxy-9-chloro-7-(2,6-difluorophenyl)pyrimido[1,2-a][1,4]benzodiazepine-3(5H)-one was heated in pyridine with lithium iodide to give 9-chloro-7-(2,6-difluorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Sources & evidence

ORD record
ord-4a300b51d3ae48e4bdae8550f3b87b79
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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