Lithium iodide → HCID 22153692, compound

HRID 1111222Notes

Reaction equation

HRID 1111222 reaction equation
C([C:6]1[N:11]2[C:12]3[CH:27]=[C:26]([CH3:28])[CH:25]=[C:24]([CH3:29])[C:13]=3[C:14]([C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)=[N:15][CH2:16][C:10]2=[N:9][C:8](=[O:30])[CH:7]=1)(OCC)=O.[I-].[Li+]>N1C=CC=CC=1>[CH3:29][C:24]1[C:13]2[C:14]([C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)=[N:15][CH2:16][C:10]3[N:11]([CH:6]=[CH:7][C:8](=[O:30])[N:9]=3)[C:12]=2[CH:27]=[C:26]([CH3:28])[CH:25]=1

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 22153741HCID 22153741, compound

Product 1

HCID 22153692HCID 22153692, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In the manner given in Example 32, 1-carboethoxy-8,10-dimethyl-7-(p-fluorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one was heated in pyridine with lithium iodide to give 8,10-dimethyl-7-(p-fluorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Sources & evidence

ORD record
ord-743fee596cca410c917817dc81c3bf71
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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