Succinic anhydride → HCID 131716736, compound

HRID 1111225Notes

Reaction equation

HRID 1111225 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[CH:13][C:14](=[O:16])[N:15]=[C:10]3[CH:9]([OH:17])[N:8]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:6]=2[CH:24]=1.[C:25]1(=[O:31])[O:30][C:28](=[O:29])[CH2:27][CH2:26]1>N1C=CC=CC=1>[C:25]([OH:30])(=[O:31])[CH2:26][CH2:27][C:28]([OH:16])=[O:29].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[CH:13][C:14](=[O:16])[N:15]=[C:10]3[CH:9]([OH:17])[N:8]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:6]=2[CH:24]=1.[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[CH:13][C:14](=[O:16])[N:15]=[C:10]3[CH:9]([OH:17])[N:8]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:6]=2[CH:24]=1

Participants

4

Reactant 2

HCID 7922Succinic anhydrideHCID 15079825HCID 15079825, compound

Product 1

HCID 131716736HCID 131716736, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A suspension of 9-chloro-5-hydroxy-7-phenylpyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one in pyridine was stirred for 3 hours with succinic anhydride. The mixture was then poured in ice water, the solid collected on filter and recrystallized from methanol-water to give 9-chloro-5-hydroxy-7-phenylpyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one hemisuccinate.

Workup

  1. customthe solid collected
  2. filtrationon filter
  3. customrecrystallized from methanol-water

Sources & evidence

ORD record
ord-541e7cd029d44e9ba17c35495709fe83
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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