Sodium → HCID 15079826, compound

HRID 1111226Notes

Reaction equation

HRID 1111226 reaction equation
C(O)(=O)C.[Cl:5][C:6]1[CH:7]=[CH:8][C:9]2[N:15]3[CH:16]=[CH:17][C:18](=[O:20])[N:19]=[C:14]3[CH:13]([OH:21])[N:12]=[C:11]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[Cl:28])[C:10]=2[CH:29]=1.[Na]>C(O)C>[Cl:5][C:6]1[CH:7]=[CH:8][C:9]2[N:15]3[CH:16]=[CH:17][C:18](=[O:20])[N:19]=[C:14]3[CH:13]([OH:21])[N:12]=[C:11]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[Cl:28])[C:10]=2[CH:29]=1

Participants

4

Reactant 2

HCID 5360545SodiumHCID 22153693HCID 22153693, compound

Product 1

HCID 15079826HCID 15079826, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 42, 9-chloro-5-hydroxy-7-(o-chlorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one acetate was hydrolyzed in ethanol with aqueous sodium hydroixde to give 9-chloro-5-hydroxy-7-(o-chlorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Sources & evidence

ORD record
ord-df6a03ec99644365a6ca6649cf7594f2
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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