N,N'-Dicyclohexylurea → HCID 53809205, compound

HRID 1111308Notes

Reaction equation

[C:1]([N:11]1[CH2:34][CH2:33][CH2:32][C@H:12]1[C:13]([NH:15][C:16]1[CH:17]=[C:18]([NH:25][C:26](=[O:31])[C:27]([F:30])([F:29])[F:28])[C:19](=[CH:23][CH:24]=1)[C:20]([OH:22])=O)=[O:14])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].C1(N=C=NC2CCCCC2)CCCCC1.C1(NC(NC2CCCCC2)=O)CCCCC1>C(OCC)(=O)C>[C:1]([N:11]1[CH2:34][CH2:33][CH2:32][C@H:12]1[C:13]([NH:15][C:16]1[CH:24]=[CH:23][C:19]2[C:20](=[O:22])[O:31][C:26]([C:27]([F:30])([F:28])[F:29])=[N:25][C:18]=2[CH:17]=1)=[O:14])([O:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)=[O:2]

Participants

Conditions

Temperature: 0 °C

Procedure

A solution was prepared by dissolving 100 mg of 4-(N-carbobenzoxy-L-prolyl)amino-N-trifluoroacetyl-anthranilic acid in 1 ml of dry ethyl acetate and cooled to a temperature of 0° C. The solution was mixed with 49 mg of N,N'-dicyclohexylcarbodiimide and the resultant mixture was stirred at a temperature of 4° C. for 18 hours. The resultant deposit consisting of N,N'-dicyclohexylurea and separated from the mixture was removed by filtration.

Workup

customA solution was prepared
customseparated from the mixture
customwas removed by filtration

Sources & evidence

ORD record: ord-fa65920b836d4da5bffb037599242ae2
Source dataset: uspto-grants-1990_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04980287

Reaction notes

Loading…