反应详情

3 g of 6,7,8-trifluoro-1,4-dihydro-4-oxo-1-(4-fluoro-phenyl)-quinoline-3-carboxylic acid are refluxed in 30 ml of pyridine with 2.7 g of N-methylpiperazine for 6 hours. The solvent is distilled off in vacuo, the residue is taken up in 30 ml of water and the precipitate is filtered off cold with suction, washed with water, dried in vacuo over calcium chloride at 100° C. and recrystallized from glycol monomethyl ether.

1. distillationThe solvent is distilled off in vacuo
2. filtrationthe precipitate is filtered off cold with suction
3. washwashed with water
4. dry with materialdried in vacuo over calcium chloride at 100° C.
5. customrecrystallized from glycol monomethyl ether