HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → HCID 57426886, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | HCID 13733157 | HCID 13733157 | — |
| Product | HCID 57426886 | HCID 57426886 | 78% |
Reaction Steps
The synthesis is carried out analogously to Example 1. 6,7,8-Trifluoro-1,4-dihydro-4-oxo-1-(4-chlorophenyl)-quinoline-3-carboxylic acid and N-methylpiperazine are used as starting substances. The corresponding quinoline-3-carboxylic acid hydrochloride (I) (R=4--Cl--C6H4 --, X1 =X2 =F, A=4-ethyl-1-piperazinyl) of melting point >300° C. is obtained in 78% yield. Melting point of the betaine: 274°-278° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04980353 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-cb40e9f80b7149718f11134e9fbc0ef3 |
| Source note | uspto-grants-1990_12 |