1-Methylpiperazine → HCID 57426886, compound

HRID 1111341Notes

Reaction equation

HRID 1111341 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[C:10](F)[C:11]=1F)[N:8](C1C=CC([Cl:20])=CC=1)[CH:7]=[C:6]([C:21]([OH:23])=[O:22])[C:5]2=O.CN1CCNCC1>>[ClH:20].[N:8]1[C:9]2[C:4](=[CH:3][CH:2]=[CH:11][CH:10]=2)[CH:5]=[C:6]([C:21]([OH:23])=[O:22])[CH:7]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 13733157HCID 13733157, compound

Product 1

HCID 57426886HCID 57426886, compoundYield 78%

Procedure

The synthesis is carried out analogously to Example 1. 6,7,8-Trifluoro-1,4-dihydro-4-oxo-1-(4-chlorophenyl)-quinoline-3-carboxylic acid and N-methylpiperazine are used as starting substances. The corresponding quinoline-3-carboxylic acid hydrochloride (I) (R=4--Cl--C6H4 --, X1 =X2 =F, A=4-ethyl-1-piperazinyl) of melting point >300° C. is obtained in 78% yield. Melting point of the betaine: 274°-278° C.

Sources & evidence

ORD record
ord-cb40e9f80b7149718f11134e9fbc0ef3
Source dataset
uspto-grants-1990_12
Patent number
US04980353

Reaction notes

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