Phosphorus pentachloride → 2,4-Dimethylthiazole-5-carbonyl chloride

HRID 1111398Notes

Reaction equation

HRID 1111398 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:8]([OH:10])=O)=[C:5]([CH3:7])[N:6]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:12]>C1(C)C=CC=CC=1>[CH3:1][C:2]1[S:3][C:4]([C:8]([Cl:12])=[O:10])=[C:5]([CH3:7])[N:6]=1

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 736488Dimethyl-1,3-thiazole-5-carboxylic acid

Product 1

HCID 146531402,4-Dimethylthiazole-5-carbonyl chloride

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

9.30 g of 2,4-dimethylthiazole-5-carboxylic acid was suspended in 90 ml of toluene, and 15.0 g of phosphorus pentachloride was added. The mixture was refluxed for 1 hour. Under reduced pressure, the resulting phosphorus oxychloride and the toluene were evaporated to give 2,4-dimethylthiazole-5-carboxylic acid chloride which was used in the following reaction without purification.

Workup

  1. temperatureThe mixture was refluxed for 1 hour
  2. customUnder reduced pressure, the resulting phosphorus oxychloride and the toluene were evaporated

Sources & evidence

ORD record
ord-858a2e8dc0d349d9b01f90b2ea25aed9
Source dataset
uspto-grants-1990_12
Patent number
US04980363

Reaction notes

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