HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus pentachloride → 2,4-Dimethylthiazole-5-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | Dimethyl-1,3-thiazole-5-carboxylic acid | HCID 736488 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2,4-Dimethylthiazole-5-carbonyl chloride | HCID 14653140 | — |
Reaction Steps
9.30 g of 2,4-dimethylthiazole-5-carboxylic acid was suspended in 90 ml of toluene, and 15.0 g of phosphorus pentachloride was added. The mixture was refluxed for 1 hour. Under reduced pressure, the resulting phosphorus oxychloride and the toluene were evaporated to give 2,4-dimethylthiazole-5-carboxylic acid chloride which was used in the following reaction without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04980363 |
| Source dataset | uspto-grants-1990_12 |
| ORD ID | ord-858a2e8dc0d349d9b01f90b2ea25aed9 |
| Source note | uspto-grants-1990_12 |