Triethylamine → HCID 22766272, compound

HRID 1111565Notes

Reaction equation

HRID 1111565 reaction equation
[CH2:1]([O:5][CH:6]([O:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH2:7][NH2:8])[CH2:2][CH2:3][CH3:4].Br[CH2:15][CH:16]1[O:20][CH:19]([CH3:21])[CH:18]([CH3:22])[O:17]1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH2:10]([O:9][CH:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[CH2:7][NH:8][CH2:15][CH:16]1[O:20][CH:19]([CH3:21])[CH:18]([CH3:22])[O:17]1)[CH2:11][CH2:12][CH3:13]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 128944572-Bromomethyl-4,5-dimethyl-1,3-dioxolaneHCID 19069548HCID 19069548, compound

Product 1

HCID 22766272HCID 22766272, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2,2-Dibutoxyethylamine (0.11 mole), 2-bromomethyl-4,5-dimethyl-1,3-dioxolane (0.1 mole), triethylamine (20 ml) and toluene (150 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction is heated at reflux for a period of about 12 hours. After this time the reaction mixture is allowed to cool to room temperature and is filtered. The reaction mixture is then stripped of solvent and unreacted starting materials under reduced pressure to yield the desired product N-(2,2dibutoxyethyl)-N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)amine.

Workup

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureThe reaction is heated
  4. temperatureat reflux for a period of about 12 hours
  5. filtrationis filtered

Sources & evidence

ORD record
ord-c45aff7b2654493d825302e7a0728f65
Source dataset
uspto-grants-1978_10
Patent number
US04118216

Reaction notes

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