Phthalic Anhydride → Phthalimidomethanesulfonic acid potassium salt

HRID 1111704Notes

Reaction equation

HRID 1111704 reaction equation
[NH2:1][CH2:2][S:3]([OH:6])(=[O:5])=[O:4].C([O-])(=O)C.[K+:11].[C:12]1(=O)[O:17][C:15](=[O:16])[C:14]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:13]12>C(O)(=O)C>[K+:11].[C:12]1(=[O:17])[N:1]([CH2:2][S:3]([O-:6])(=[O:5])=[O:4])[C:15](=[O:16])[C:14]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:13]12

Participants

5

Reactant 3

HCID 6811Phthalic AnhydrideHCID 83791Aminomethanesulfonic acidHCID 517044Potassium Acetate

Product 1

HCID 88789710Phthalimidomethanesulfonic acid potassium salt

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A suspension of 15.1 g. (0.136 mol.) of aminomethanesulfonic acid and 14.2 g. (0.145 mol.) of anhydrous potassium acetate in 48 ml. of acetic acid is refluxed for 10 minutes. Phthalic anhydride (21.4 g., 0.145 mol.) is then added and the resulting mixture is refluxed for 2.5 hours. The product is collected by filtration and washed with acetic acid and ethanol to give phthalimidomethanesulfonic acid potassium salt.

Workup

  1. additionA suspension of 15.1 g
  2. temperaturethe resulting mixture is refluxed for 2.5 hours
  3. filtrationThe product is collected by filtration
  4. washwashed with acetic acid and ethanol

Sources & evidence

ORD record
ord-60f4f0b28a1f4946ae4d5a64f89e0a27
Source dataset
uspto-grants-1978_10
Patent number
US04118490

Reaction notes

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