Formaldehyde → 3-Morpholino-2-(2-pyrimidyl)propionitrile

HRID 1111729Notes

Reaction equation

HRID 1111729 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][C:8]#[N:9].[CH2:10]=O.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>CO>[O:15]1[CH2:16][CH2:17][N:12]([CH2:10][CH:7]([C:2]2[N:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[C:8]#[N:9])[CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8083MorpholineHCID 15264944(Pyrimidin-2-yl)acetonitrile

Product 1

HCID 227678033-Morpholino-2-(2-pyrimidyl)propionitrile

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The above prepared 2-(2-pyrimidyl)acetonitrile is reacted with formaldehyde and morpholine in methanol to give 3-morpholino-2-(2-pyrimidyl)propionitrile.

Sources & evidence

ORD record
ord-a6d473b91d574987b5429fbe2f6a2ddb
Source dataset
uspto-grants-1978_10
Patent number
US04118567

Reaction notes

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