Hydrogen Bromide → 1-Methyl-3-phenyl-5-(2-bromomethylphenyl)-1,2,4-triazole

HRID 1111866Notes

Reaction equation

HRID 1111866 reaction equation
[BrH:1].[CH3:2][N:3]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH2:14]O)=[N:6][C:5]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[N:4]1>ClCCl>[CH3:2][N:3]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH2:14][Br:1])=[N:6][C:5]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[N:4]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 218245361-Methyl-3-phenyl-5-(2-hydroxymethylphenyl)-1,2,4-triazole

Product 1

HCID 213219351-Methyl-3-phenyl-5-(2-bromomethylphenyl)-1,2,4-triazoleYield 84%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 300 ml. of dichloromethane saturated with dry hydrogen bromide 7 g. of 1-methyl-3-phenyl-5-(2-hydroxymethylphenyl)-1,2,4-triazole are added. The solution is allowed to stand at room temperature for a night and after washing with aqueous sodium bicarbonate and then with water it is dried over sodium sulfate. Evaporation of the solvent and crystallization from hexane afford the title compound. M.p. 83°-85° C. Yield 84%.

Workup

  1. waitto stand at room temperature for a night
  2. washafter washing with aqueous sodium bicarbonate
  3. dry with materialwith water it is dried over sodium sulfate
  4. customEvaporation of the solvent and crystallization from hexane

Sources & evidence

ORD record
ord-c7ff0bb952654572b4fc4dd108362412
Source dataset
uspto-grants-1978_10
Patent number
US04119635

Reaction notes

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