Hydrochloric Acid → HCID 41997, compound

HRID 1111939Notes

Reaction equation

Cl.Cl.[NH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:17])[CH2:11][NH:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:6][C:5]=1[F:18].[BH4-].[Na+]>>[NH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([OH:17])[CH2:11][NH:12][C:13]([CH3:14])([CH3:16])[CH3:15])=[CH:6][C:5]=1[F:18]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 4311764Sodium borohydride

HCID 22765823HCID 22765823, compound

Product 1

HCID 41997HCID 41997, compound

Procedure

m.p. of the hydrochloride: 196°-197° C. (decomp.), was prepared from 4'-amino-2-tert.butylamino-3'-fluoro-acetophenone hydrochloride and sodium borohydride analogous to Example 1.

Sources & evidence

ORD record: ord-54a59339f2644b7ea5baf4ac38b005d4
Source dataset: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04119710

Reaction notes

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