Hydrochloric Acid → HCID 13355531, compound

HRID 1111944Notes

Reaction equation

HRID 1111944 reaction equation
Cl.Cl.[NH2:3][C:4]1[C:9]([F:10])=[CH:8][C:7]([C:11](=[O:17])[CH2:12][NH:13][CH:14]2[CH2:16][CH2:15]2)=[CH:6][C:5]=1[Cl:18].[BH4-].[Na+]>>[NH2:3][C:4]1[C:9]([F:10])=[CH:8][C:7]([CH:11]([OH:17])[CH2:12][NH:13][CH:14]2[CH2:16][CH2:15]2)=[CH:6][C:5]=1[Cl:18]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 22765872HCID 22765872, compound

Product 1

HCID 13355531HCID 13355531, compound

Procedure

m.p. of the hydrochloride: 175°-177° C. (decomp.), was prepared from 4'-amino-3'-chloro-2-cyclopropylamino-5'-fluoro-acetophenone hydrochloride and sodium borohydride analogous to Example 1.

Sources & evidence

ORD record
ord-341e770fa14445aa833add9e300f01b4
Source dataset
uspto-grants-1978_10
Patent number
US04119710

Reaction notes

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