Hydrochloric Acid → HCID 41999, compound

HRID 1111945Notes

Reaction equation

Cl.Cl.[NH2:3][C:4]1[C:9]([F:10])=[CH:8][C:7]([C:11](=[O:18])[CH2:12][NH:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:6][C:5]=1[Cl:19].[BH4-].[Na+]>>[NH2:3][C:4]1[C:9]([F:10])=[CH:8][C:7]([CH:11]([OH:18])[CH2:12][NH:13][C:14]([CH3:15])([CH3:17])[CH3:16])=[CH:6][C:5]=1[Cl:19]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 4311764Sodium borohydride

HCID 22765848HCID 22765848, compound

Product 1

HCID 41999HCID 41999, compound

Procedure

m.p. of the hydrochloride: 206°-208° C. (decomp.), was prepared from 4'-amino-2-tert.butylamino-3'-chloro-5'-fluoro-acetophenone hydrochloride and sodium borohydride analogous to Example 1.

Sources & evidence

ORD record: ord-c3657bdf20014a4aab4771ff10e12a02
Source dataset: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04119710

Reaction notes

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