Hydrochloric Acid → HCID 13355536, compound

HRID 1111946Notes

Reaction equation

Cl.Cl.[NH2:3][C:4]1[C:9]([F:10])=[CH:8][C:7]([C:11](=[O:19])[CH2:12][NH:13][C:14]([CH2:17][CH3:18])([CH3:16])[CH3:15])=[CH:6][C:5]=1[Cl:20].[BH4-].[Na+]>>[NH2:3][C:4]1[C:9]([F:10])=[CH:8][C:7]([CH:11]([OH:19])[CH2:12][NH:13][C:14]([CH2:17][CH3:18])([CH3:15])[CH3:16])=[CH:6][C:5]=1[Cl:20]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 4311764Sodium borohydride

HCID 22765874HCID 22765874, compound

Product 1

HCID 13355536HCID 13355536, compound

Procedure

m.p. of the hydrochloride: 187°-188° C. (decomp.), was prepared from 4'-amino-3'-chloro-5'-fluoro-2-tert.pentylamino-acetophenone hydrochloride and sodium borohydride analogous to Example 1.

Sources & evidence

ORD record: ord-d7553e6e953c44c39aaa957243d46d45
Source dataset: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04119710

Reaction notes

Loading…