Hydrochloric Acid → HCID 13355555, compound

HRID 1111947Notes

Reaction equation

Cl.Cl.[NH2:3][C:4]1[C:9]([F:10])=[CH:8][C:7]([C:11](=[O:17])[CH2:12][NH:13][CH:14]([CH3:16])[CH3:15])=[CH:6][C:5]=1[Br:18].[BH4-].[Na+]>>[NH2:3][C:4]1[C:9]([F:10])=[CH:8][C:7]([CH:11]([OH:17])[CH2:12][NH:13][CH:14]([CH3:15])[CH3:16])=[CH:6][C:5]=1[Br:18]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 4311764Sodium borohydride

HCID 22765849HCID 22765849, compound

Product 1

HCID 13355555HCID 13355555, compound

Procedure

m.p. of the hydrochloride: 171°-173° C. (decomp.), was prepared from 4'-amino-3'-bromo-5'-fluoro-2-isopropylamino-acetophenone hydrochloride and sodium borohydride analogous to Example 1.

Sources & evidence

ORD record: ord-cb4b4d3916ac4422ad9c5078e24004b7
Source dataset: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04119710

Reaction notes

Loading…