Hydrochloric Acid → HCID 13355553, compound

HRID 1111948Notes

Reaction equation

Cl.[NH2:2][C:3]1[C:8]([F:9])=[CH:7][C:6]([C:10](=[O:16])[CH2:11][NH:12][CH:13]2[CH2:15][CH2:14]2)=[CH:5][C:4]=1[Br:17].[BH4-].[Na+]>>[NH2:2][C:3]1[C:8]([F:9])=[CH:7][C:6]([CH:10]([OH:16])[CH2:11][NH:12][CH:13]2[CH2:15][CH2:14]2)=[CH:5][C:4]=1[Br:17]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 4311764Sodium borohydride

HCID 13355541HCID 13355541, compound

Product 1

HCID 13355553HCID 13355553, compound

Procedure

m.p. of the hydrochloride: 185°-187° C. (decomp.), was prepared from 4'-amino-3'-bromo-2-cyclopropylamino-5'-fluoro-acetophenone and sodium borohydride analogous to Example 1.

Sources & evidence

ORD record: ord-28c71b710abd431ab49fb4ed5cfdd505
Source dataset: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04119710

Reaction notes

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