Hydrochloric Acid → HCID 13355558, compound

HRID 1111950Notes

Reaction equation

Cl.Cl.[NH2:3][C:4]1[C:9]([F:10])=[CH:8][C:7]([C:11](=[O:19])[CH2:12][NH:13][C:14]([CH2:17][CH3:18])([CH3:16])[CH3:15])=[CH:6][C:5]=1[Br:20].[BH4-].[Na+]>>[NH2:3][C:4]1[C:9]([F:10])=[CH:8][C:7]([CH:11]([OH:19])[CH2:12][NH:13][C:14]([CH2:17][CH3:18])([CH3:15])[CH3:16])=[CH:6][C:5]=1[Br:20]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 4311764Sodium borohydride

HCID 22765850HCID 22765850, compound

Product 1

HCID 13355558HCID 13355558, compound

Procedure

m.p. of the hydrochloride: 185°-187° C. (decomp.), was prepared from 4'-amino-3'-bromo-5'-fluoro-2-tert.pentylamino-acetophenone hydrochloride and sodium borohydride analogous to Example 1.

Sources & evidence

ORD record: ord-ccd39a29b9ca48aca3e38d15550397bc
Source dataset: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04119710

Reaction notes

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