Hydrochloric Acid → Mapenterol

HRID 1111953Notes

Reaction equation

HRID 1111953 reaction equation
Cl.Cl.[NH2:3][C:4]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][C:7]([C:14](=[O:22])[CH2:15][NH:16][C:17]([CH2:20][CH3:21])([CH3:19])[CH3:18])=[CH:6][C:5]=1[Cl:23].[BH4-].[Na+]>>[NH2:3][C:4]1[C:9]([C:10]([F:11])([F:12])[F:13])=[CH:8][C:7]([CH:14]([OH:22])[CH2:15][NH:16][C:17]([CH2:20][CH3:21])([CH3:19])[CH3:18])=[CH:6][C:5]=1[Cl:23]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 22765890HCID 22765890, compound

Product 1

HCID 178787Mapenterol

Procedure

m.p. of the hydrochloride: 176°-178° C. (decomp.), was prepared from 4'-amino-3'-chloro-2-tert.pentylamino-5'-trifluoromethyl-acetophenone hydrochloride and sodium borohydride analogous to Example 1.

Sources & evidence

ORD record
ord-5dfbe91b86ee4a3ebb91a75a09ebb78c
Source dataset
uspto-grants-1978_10
Patent number
US04119710

Reaction notes

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