Hydrochloric Acid → HCID 13355647, compound

HRID 1111955Notes

Reaction equation

HRID 1111955 reaction equation
Cl.Cl.[NH2:3][C:4]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][C:7]([C:14](=[O:20])[CH2:15][NH:16][CH:17]2[CH2:19][CH2:18]2)=[CH:6][C:5]=1[Br:21].[BH4-].[Na+]>>[NH2:3][C:4]1[C:9]([C:10]([F:11])([F:12])[F:13])=[CH:8][C:7]([CH:14]([OH:20])[CH2:15][NH:16][CH:17]2[CH2:18][CH2:19]2)=[CH:6][C:5]=1[Br:21]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 22765835HCID 22765835, compound

Product 1

HCID 13355647HCID 13355647, compound

Procedure

m.p. 141.5°-142.5° C., m.p. of the hydrochloride: 195°-195.5° C. (decomp.), was prepared from 4'-amino-3'-bromo-2-cyclopropylamino-5'-trifluoromethyl-acetophenone hydrochloride and sodium borohydride analogous to Example 1.

Sources & evidence

ORD record
ord-345e4c62aa6d4b068a57de4383f6c50d
Source dataset
uspto-grants-1978_10
Patent number
US04119710

Reaction notes

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