Hydrochloric Acid → HCID 13355648, compound

HRID 1111956Notes

Reaction equation

HRID 1111956 reaction equation
Cl.Cl.[NH2:3][C:4]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][C:7]([C:14](=[O:21])[CH2:15][NH:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:6][C:5]=1[Br:22].[BH4-].[Na+]>>[NH2:3][C:4]1[C:9]([C:10]([F:11])([F:12])[F:13])=[CH:8][C:7]([CH:14]([OH:21])[CH2:15][NH:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[CH:6][C:5]=1[Br:22]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 86736063HCID 86736063, compound

Product 1

HCID 13355648HCID 13355648, compound

Procedure

m.p. 85°-87° C., m.p. of the hydrochloride: 205°-206° C. (decomp.), was prepared from 4'-amino-3'-bromo-2-tert. butylamino-5'-trifluoromethyl-acetophenone hydrochloride and sodium borohydride analogous to Example 1.

Sources & evidence

ORD record
ord-30538706546044399cd8c6d054ac8a26
Source dataset
uspto-grants-1978_10
Patent number
US04119710

Reaction notes

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