Hydrochloric Acid → HCID 13355641, compound

HRID 1111957Notes

Reaction equation

HRID 1111957 reaction equation
Cl.Cl.[NH2:3][C:4]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][C:7]([C:14](=[O:21])[CH2:15][NH:16][CH:17]2[CH2:20][CH2:19][CH2:18]2)=[CH:6][C:5]=1[Br:22].[BH4-].[Na+]>>[NH2:3][C:4]1[C:9]([C:10]([F:11])([F:12])[F:13])=[CH:8][C:7]([CH:14]([OH:21])[CH2:15][NH:16][CH:17]2[CH2:18][CH2:19][CH2:20]2)=[CH:6][C:5]=1[Br:22]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 22765861HCID 22765861, compound

Product 1

HCID 13355641HCID 13355641, compound

Procedure

m.p. of the hydrochloride: 189°-191° C. (decomp.), was prepared from 4'-amino-3'-bromo-2-cyclobutylamino-5'-trifluoromethyl-acetophenone hydrochloride and sodium borohydride analogous to Example 1.

Sources & evidence

ORD record
ord-6d6082a60edf467d91c3267f6a956e37
Source dataset
uspto-grants-1978_10
Patent number
US04119710

Reaction notes

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