Hydrochloric Acid → HCID 42003, compound

HRID 1111961Notes

Reaction equation

Cl.[NH2:2][C:3]1[C:8]([C:9]#[N:10])=[CH:7][C:6]([C:11](=[O:18])[CH2:12][NH:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:5][C:4]=1[Br:19].[BH4-].[Na+]>>[NH2:2][C:3]1[C:8]([C:9]#[N:10])=[CH:7][C:6]([CH:11]([OH:18])[CH2:12][NH:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[CH:5][C:4]=1[Br:19]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 4311764Sodium borohydride

HCID 13355655HCID 13355655, compound

Product 1

HCID 42003HCID 42003, compound

Procedure

m.p. of the hydrochloride: 213°-214° C., was prepared from 4'-amino-3'-bromo-2-tert.butylamino-5'-cyano-acetophenone and sodium borohydride analogous to Example 2.

Sources & evidence

ORD record: ord-81bc1ef0d0744369810e7068274c4e85
Source dataset: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04119710

Reaction notes

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