Hydrochloric Acid → HCID 13355562, compound

HRID 1111968Notes

Reaction equation

HRID 1111968 reaction equation
Cl.[NH2:2][C:3]1[C:8]([F:9])=[CH:7][C:6]([C:10](=[O:18])[CH2:11][NH:12][CH:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[CH:5][C:4]=1[Br:19].[BH4-].[Na+]>>[NH2:2][C:3]1[C:8]([F:9])=[CH:7][C:6]([CH:10]([OH:18])[CH2:11][NH:12][CH:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[CH:5][C:4]=1[Br:19]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 13355548HCID 13355548, compound

Product 1

HCID 13355562HCID 13355562, compound

Procedure

m.p. of the hydrochloride: 167°-170° C. (decomp.), was prepared from 4'-amino-3'-bromo-2-cyclopentylamino-5'-fluoroacetophenone and sodium borohydride analogous to Example 49.

Sources & evidence

ORD record
ord-c351c72fb29c4a7686ab173ba543ba78
Source dataset
uspto-grants-1978_10
Patent number
US04119710

Reaction notes

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