Hydrochloric Acid → HCID 13355574, compound

HRID 1111970Notes

Reaction equation

Cl.[NH2:2][C:3]1[C:8]([I:9])=[CH:7][C:6]([C:10](=[O:16])[CH2:11][NH:12][CH:13]2[CH2:15][CH2:14]2)=[CH:5][C:4]=1[F:17].[BH4-].[Na+]>>[NH2:2][C:3]1[C:8]([I:9])=[CH:7][C:6]([CH:10]([OH:16])[CH2:11][NH:12][CH:13]2[CH2:15][CH2:14]2)=[CH:5][C:4]=1[F:17]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 4311764Sodium borohydride

HCID 13355570HCID 13355570, compound

Product 1

HCID 13355574HCID 13355574, compound

Procedure

m.p. of the hydrochloride: 199°-201° C. (decomp.), was prepared from 4'-amino-2-cyclopropylamino-3'-fluoro-5'-iodo-acetophenone and sodium borohydride analogous to Example 49.

Sources & evidence

ORD record: ord-69fd6006d12246118ddac3658f87d4fd
Source dataset: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04119710

Reaction notes

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